Low fat vs. low carbohydrate Many studies have focused on diets that reduce calories via low-carbohydrate diets (the Atkins diet, Zone diet) vs. low-fat diet (LEARN diet, Ornish diet). The Nurses’ Health Study, an observational cohort study, found that low carbohydrate diets based on vegetable sources of protein is associated with graceful less coronary artery disease. A meta-analysis of randomized controlled studies by the International Cochrane Collaboration conducted in 2002 concluded that diets that restrict fat are no better than diets that restrict calories to achieve weight loss long term in overweight or obese.A more recent meta-analysis that included controlled studies published after the Cochrane review, found that “diets low in carbohydrates, which is not restricted energy seem to be at least as effective as low-fat diets with energy restriction in Indian and weight loss up to a year.However, potentially favorable changes in triglycerides and HDL cholesterol should be weighed against potential unfavorable changes in LDL cholesterol level, when using low carbohydrate diets to induce weight loss. ” The Women’s Health Initiative Randomized Controlled Dietary Modification Trial found that a diet with a total of 20 of energy from the energy and increased consumption of vegetables and fruit to at least 5 servings daily and grains to at least 6 servings daily resulted in: there was no reduction in cardiovascular disease, there was a nonsignificant reduction of invasive breast cancer and there was no reduction in colorectal cancer. Recent randomized controlled studies have further found that: A comparison of the Atkins diet, Zone diet, Ornish diet and LEARN diet in premenopausal women, found the greatest benefit from the Atkins diet. The choice of diet for a specific person can be influencedmeasuring individual insulin secretion: In young adults “Reducing glycemic load (carbohydrates) can NSER especially important to achieve weight loss among individuals with high insulin secretion.” This is consistent with previous studies of patients diabetes in which low-carbohydrate diets were more beneficial.